Characterization of Protein Based Medicines using Drop Coat Deposition Raman Spectroscopy

14:00 - 14:35

Biologics drugs are substantially more challenging to characterize than small molecule based pharmaceuticals due to complexity of the molecule and analytical ability to accurately determine its protein secondary structure. Drop Coat Deposition Raman (DCDR) spectroscopy has been utilized for fingerprinting of BMS biologics and has been successfully used in differentiating counterfeit biologics from their authentic counterpart. DCDR spectroscopy is also being further explored for other applications such as degradation studies of biologics to understand how some of the stress conditions affect the secondary structure of the protein in the formulation. This talk focuses on the DCDR spectroscopy and its capabilities for effective characterization of changes in secondary structure of protein that can be applicable for upstream and downstream in manufacturing.

Anna Luczak, Senior Scientist, Bristol-Myers Squibb