Trehalose and Sucrose: Essential Components of Platform Biopharma Formulations

11:35 - 12:10

  • Commercial Biotherapeutics Stabilized with Trehalose
  • Commercial Biotherapeutics Stabilized with Sucrose
  • Key Issues in Biopharma Formulation Development
  • Essential components of a “Platform Biopharma Formulation”
  • Understanding important physicochemical properties of Trehalose and Sucrose
    • Instability of sucrose at low pH – free glucose, protein glycation
    • Phase transition and crystallization of trehalose
    • Importance of Control of Glucose levels in Sucrose as well as Trehalose
  • Purity, Quality, Consistency in Pfanstiehl’s Trehalose and Sucrose
    • β-glucans in sucrose – interference with endotoxins
    • Trace metal specifications for Sucrose and Trehalose
  • Advantages of Trehalose over Sucrose
  • Pfanstiehl’s Biopharma Stabilization Portfolio incld. newly launched L-Arginine  and L-Histidine
  • Conclusions

Dr. Christian Lotz, General Manager, EMEA, Pfanstiehl