Parenteral administration of biopharmaceuticals for intestinal diseases is associated with numerous disadvantages e.g. low patient compliance, and toxicity caused by high systemic bioavailability. One alternative that can potentially overcome these limitations is oral administration of biopharmaceuticals, where the local delivery will reduce the systemic exposure and furthermore the manufacturing costs will be lower.
Electrospinning is a new promising drying technology for biopharmaceuticals as drying takes place at low temperature coupled with a possibility to make nanosized fibers. The technology will be discussed and compared to traditional drying technologies.