Trehalose and Sucrose: Essential Components of Platform Biopharma Formulations

12:25 - 13:00

  • Commercial Biotherapeutics Stabilized with Trehalose
  • Commercial Biotherapeutics Stabilized with Sucrose
  • Key Issues in Biopharma Formulation Development
  • Essential components of a “Platform Biopharma Formulation”
  • Understanding important physicochemical properties of Trehalose and Sucrose
    • Instability of sucrose at low pH – free glucose, protein glycation
    • Phase transition and crystallization of trehalose
  • Purity, Quality, Consistency in Pfanstiehl’s Trehalose and Sucros
    • β-glucans in sucrose – interference with endotoxins
    • Trace metal specifications for Sucrose and Trehalose
  • Advantages of Trehalose over Sucrose
  • Pfanstiehl’s Biopharma Stabilization Portfolio

Dr. Christian Lotz, General Manager EMEA, Pfanstiehl GMBH