
- Hydrophobic drugs having low bioavailability can be formulated in bile-salt containing mixed micelles
- Those mixed micelles can be stabilized in gastric conditions by a few different ways, including PEGylation
- PEGylated mixed micelles show good mucus penetration and transport through endothelial cells
- PEGylated mixed micelles are designed to provide proper bioavailability even under cholestatic conditions
Rene Van Nostrum, Associate Professor, Utrecht University