Oral delivery of hydrophobic drugs using mixed micelles

3/13/2018 12:10 - 12:45

  • Hydrophobic drugs having low bioavailability can be formulated in bile-salt containing mixed micelles
  • Those mixed micelles can be stabilized in gastric conditions by a few different ways, including PEGylation
  • PEGylated mixed micelles show good mucus penetration and transport through endothelial cells
  • PEGylated mixed micelles are designed to provide proper bioavailability even under cholestatic conditions

Rene Van Nostrum, Associate Professor, Utrecht University