Oral delivery of hydrophobic drugs using mixed micelles
12:10 - 12:45
- Hydrophobic drugs having low bioavailability can be formulated in bile-salt containing mixed micelles
- Those mixed micelles can be stabilized in gastric conditions by a few different ways, including PEGylation
- PEGylated mixed micelles show good mucus penetration and transport through endothelial cells
- PEGylated mixed micelles are designed to provide proper bioavailability even under cholestatic conditions
