Microenvironmental pH Modulation – An Effective Tool in Enhancing Dissolution and Oral Absorption of Solid Dosage Forms

11:30 - 12:05

  • Pros and cons of using high-energy solids (salts, co-crystals, or amorphous solid dispersions) to generate supersaturation and enhance drug bioavailability
  • Dissolution from solid and diffusion layer model
  • Microenvironmental pH modulation to control dissolution behaviour of solid dosage forms
  • Case study in enhancing oral absorption of the salt of a weakly acidic BCS Class II compound

Helen Hao Hou, Senior Scientist Small Molecule Pharmaceutical Sciences , Genentech